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Laboratorio di Medicina Molecolare

  • Pharma/Biopharma

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Department: 
Dipartimento di Medicina Molecolare e dello Sviluppo
Public research organization: 
Università degli Studi di Siena
Web site :
https://www.dmms.unisi.it/it/dipartimento/personale/docenti/sorrentino-vincenzo
Address:
Via A. Moro, 2 - 53100 - Siena
 vincenzo.sorrentino@unisi.it
 +39 0577 234049

Overview: 

In the Laboratory of Molecular Medicine research is carried out on the cellular and genetic mechanisms related to the musculoskeletal system. In particular, it studies the organization of the sarcoplasmic reticulum and its relationship with the contractile apparatus, the mechanisms of action connected to the proteins involved in the release of calcium from the sarcoplasmic reticulum, the proteins connected to the cytoskeletal myofibrils (e.g. costameric proteins such as dystrophin). In addition, the genetic mutations responsible for the structural and functional organisation of skeletal muscle fibers, which are involved in genetic diseases (e.g. malignant hyperthermia, central core diseases and new forms of muscular myopathy and muscular dystrophy), are investigated.

Sectors :
Pharma/BiopharmaRelated activities and services

Field of Research: 
Biochemistry and cell biology
Genetics, genomics
Metabolic biochemistry
Medical and health sciences
Biological sciences
Health research areas: 
Musculoskeletal system diseases

Skills: 
"At the laboratory there are skills related to: - calcium release measures - expression of recombinant proteins in bacteria - production of antibodies - analysis of confocal microscope image - behavioural and neurochemical characterisation in animal models of active substances on the central nervous system - development of tumours in mouse models by subcutaneous and/or intracranial inoculation of tumour cells - study of the antiproliferative effect of active ingredients in vitro and in vivo
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Fondazione Toscana Life Sciences - Bando Distretti Tecnologici, Azione 1.1.6 Programma regionale Fesr 2021-2027
Fondazione Toscana Life Sciences - Bando Distretti Tecnologici, Azione 1.1.6 Programma regionale Fesr 2021-2027