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LABORATORI ARCHA

Via di Tegulaia, 10/A - 56121 - Pisa-PI

archainf@archa.it

ARCHA, an acronym for Applied CHemical Analysis and Research, was founded in 1989 by a pool of chemical professionals as a cutting-edge laboratory for analysis and research in the chemical field. Today, ARCHA has grown and expanded its activities, organized in the three sectors of Technology, ICT and Industrialization, within which different areas of competence and/or different companies of the group are referred to. ARCHA is a qualified partner for the development and characterization of innovative products in all the various phases and aspects, from conception, to research and development, start-up, environmental impact assessment, safety, management and control software, up to industrialization and commercialization. ARCHA is also a training agency for training and cultural and professional growth in technical and specialist fields.

Laboratori di Neuroimmunologia, Neurobiologia e Neuroimmagini

Viale Pieraccini, 6 - 50139 - Firenze

luca.massacesi@unifi.it

"The Laboratory of Neuroimmunology and Cell and Molecular Neurobiology is involved in clinical research (ex vivo from samples of neurological patients), and preclinical research on experimental models of disease and cell cultures. It studies biological samples (mainly blood and liquor) at cellular and molecular level taken from patients with psychiatric and autoimmune diseases, inflammatory, neurodegenerative central nervous system diseases or from animal models of neurological diseases.
The Neuroimaging Laboratory processes magnetic resonance imaging of the CNS from neurological patients after their acquisition with both conventional and unconventional techniques, for studies aimed at clinical follow-up and in real life, and observational studies of the natural history of brain lesions of these patients.
The Laboratory analyses MRI end-points in both monocentric and multicentric clinical trials, develops MRI analysis techniques for the improvement of the diagnosis of autoimmune diseases of the central nervous system.

Laboratorio di Reverse Engineering & Computer Vision, Rapid & Virtual Prototyping

Via Santa Marta, 3 - 50139 - Firenze

monica.carfagni@unifi.it

"The laboratory operates both in the context of research agreements and technology transfer commissioned by private entities and in the framework of projects funded by public bodies (regional, national, EU) in the areas of Computer vision and reverse engineering, Development methodologies and virtual prototyping, Rapid prototyping, environmental and industrial acoustics. The main areas of competence are:
- 3D scanning and reverse engineering;
- dimensional, aesthetic and colorimetric control of industrial production;
- artificial vision applied to the cultural heritage industry and sector;
- dimensional, aesthetic and colorimetric control of industrial production;
- additive manufacturing (3D printing, rapid prototyping);
- multiphysics numerical simulation (FEM, Multibody);
- mechanical design, CAD systems and design automation tools.

Laboratorio di farmacologia dell'angiogenesi

Via A. Moro, 2 - 53100 - Siena

marina.ziche@unisi.it

The Laboratory of Pharmacology of Angiogenesis conducts research on the pharmacology of angiogenesis and microcirculation, on the cellular and molecular mechanisms of physiological and pathological angiogenesis, in particular in inflammatory, degenerative and neoplastic diseases, on the characterization of pro- and antiangiogenic factors in the progression of diseases and for therapeutic exploitation, on molecular/methobic biomarkers for stability and resistance to anticancer drugs, on pharmacogenetics and personalized medicine in oncology. Research is carried out through an integrated in vitro test platform, using a wide range of cell lines (endothelial, vascular and stromal cells, human and murine cancer cells, naive and genetically modified cells), on which molecular biology studies (expression/protein activity using western blot and immunofluorescence techniques) are performed, EIA/ELISA tests for mediators and metabolic pathways, RT-PCR for gene expression, silencing and transfection of target genes) and in vitro functional tests (cell proliferation and survival, toxicity and cyto-compatibilitys, cell migration, clonogenic assay, tumour formation and many others).

Laboratorio di Medicina Molecolare

Via A. Moro, 2 - 53100 - Siena

vincenzo.sorrentino@unisi.it

In the Laboratory of Molecular Medicine research is carried out on the cellular and genetic mechanisms related to the musculoskeletal system. In particular, it studies the organization of the sarcoplasmic reticulum and its relationship with the contractile apparatus, the mechanisms of action connected to the proteins involved in the release of calcium from the sarcoplasmic reticulum, the proteins connected to the cytoskeletal myofibrils (e.g. costameric proteins such as dystrophin). In addition, the genetic mutations responsible for the structural and functional organisation of skeletal muscle fibers, which are involved in genetic diseases (e.g. malignant hyperthermia, central core diseases and new forms of muscular myopathy and muscular dystrophy), are investigated.

Laboratorio di progettazione e sintesi di API (Active Pharmaceutical Ingredients)

Via A. Moro, 2 - 53100 - Siena

maurizio.taddei@unisi.it

"API (Active Pharmaceutical Ingredients) Design and Synthesis Laboratory is involved in research and development of innovative sustainable processes for the preparation of pharmaceutical active ingredients, development of low environmental impact procedures to be applied to the production of drugs, consulting and development of ""non-improving"" synthetic methods for the production of drugs aimed at the generic market.
The laboratory has at its disposal microwave reactors, flow synthesizers, HPLC, HPLC /MS and other standard analytical instruments of organic synthesis."

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